@article{ref1,
title="Patterns of balance loss with systematic perturbations in Parkinson's disease and multiple sclerosis",
journal="NeuroRehabilitation",
year="2021",
author="Allen, Diane D. and Gadayan, Jessica and Hughes, Rebecca and Magdalin, Christine and Jang, Catherine and Schultz, Amy and Scott, Kathryn and Vivero, Leah and Lazaro, Rolando L. and Widener, Gail L.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Multiple sclerosis (MS) and Parkinson's disease (PD) may affect balance differently. However, no studies have compared loss of balance (LOB) patterns following multi-directional perturbations. <br><br>OBJECTIVE: 1) determine reliability of LOB ratings following standardized manual perturbations; 2) compare LOB ratings in MS, PD, and healthy control (HC) groups following perturbations at upper/lower torso, in anterior/posterior, right/left, and rotational directions. <br><br>METHODS: 1) reviewers rated videotaped LOB following perturbations applied by 4 clinicians in 6-10 HCs. 2) three groups (64 MS, 42 PD and 32 HC) received perturbations. LOB ratings following perturbations were analyzed using two-factor mixed ANOVAs for magnitude and prevalence. <br><br>RESULTS: 1) LOB ratings showed moderate to good ICC and good to excellent agreement. 2) MS group showed greater magnitude and prevalence of LOB than PD or HC groups (p <  .001). All groups showed greater LOB from right/left versus anterior/posterior perturbations (p <  .01). PD showed greater LOB from perturbations at upper versus lower torso; MS and HC showed greater LOB from posterior versus anterior perturbations. <br><br>CONCLUSIONS: Our reliable rating scale showed differences in patterns of LOB following manual perturbations in MS, PD, and HC. Clinically accessible and reliable assessment of LOB could facilitate targeted perturbation-based interventions and reduce falls in vulnerable populations.<p /> <p>Language: en</p>",
language="en",
issn="1053-8135",
doi="10.3233/NRE-210200",
url="http://dx.doi.org/10.3233/NRE-210200"
}