@article{ref1,
title="Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury",
journal="Journal of affective disorders",
year="2021",
author="Zhang, Yiliang and Lai, Shunkai and Wu, Weige and Wang, Ying and Zhao, Hui and He, Jiali and Zhu, Yunxia and Chen, Guangmao and Qi, Zhangzhang and Chen, Pan and Lv, Sihui and Song, Zijin and Hu, Yilei and Miao, Haofei and Yan, Shuya and Luo, Yange and Ran, Hanglin and Huang, Xiaosi and Lu, Xiaodan and Zhong, Shuming and Jia, Yanbin",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: H protons magnetic resonance spectroscopy ((1)H-MRS) has been used to detect abnormal biochemical changes and the mechanism of executive dysfunction in major depressive disorder (MDD). While, finding information associated with non-suicidal self-injury (NSSI) among adolescents with MDD is challenging. The present study aimed to examine the executive function and biochemical metabolism alterations as well as to elucidate their associations in depressed adolescents with NSSI. <br><br>METHODS: A total of 86 adolescents with MDD (40 with NSSI, and 46 without NSSI) and 28 healthy controls were recruited in the current study. The executive function was assessed by Digital symbol test (DST), Wisconsin Card Sorting Test (WCST), Trail Making Test, part B (TMT-B), and Verbal fluency (VF). Bilateral metabolite levels of the prefrontal cortex (PFC), anterior cingulated cortex (ACC), lenticular nucleus (LN) of basal ganglia and thalamus were obtained by (1)H-MRS at 3.0 T, and then the ratios of N-acetyl aspartate (NAA) and choline-containing compounds (Cho) to creatine (Cr) were determined, respectively. Finally, association analysis was conducted to investigate their relationships. <br><br>RESULTS: The depressed adolescents with NSSI showed significantly lower VF scores than those without NSSI and healthy controls. We also found significantly higher NAA/Cr ratios in the right thalamus, while significantly lower Cho/Cr ratios in the right thalamusof NSSI group than the MDD without NSSI group and healthy controls. And NSSI group also showed lower NAA/Cr ratio in the right LNthan the MDD without NSSI group. For MDD with NSSI, the NAA/Cr ratios of the left thalamus was positively correlated with the time of TMTB and the Cho/Cr ratios of the left ACC was positively correlated with the VF scores. <br><br>CONCLUSIONS: Depressed adolescents with NSSI may have executive dysfunction and an abnormal NAA and Cho metabolism in thalamus. Andthe NAA/Cr ratios of the right LN could distinguish NSSI from depressed adolescents. Further, the executive dysfunction may associated with the abnormal NAA metabolism in the right thalamus and ACC.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2021.10.132",
url="http://dx.doi.org/10.1016/j.jad.2021.10.132"
}