@article{ref1,
title="Carbon monoxide poisoning and developing ischemic heart disease: a nationwide population-based nested case-control study",
journal="Toxics (Basel)",
year="2021",
author="Bahng, Yewon and Baek, Kiook and Park, Jong-Tae and Choi, Won-Jun and Kwak, Kyeongmin",
volume="9",
number="10",
pages="-",
abstract="Although there are several case reports showing that carbon monoxide (CO) poisoning causes ischemic heart disease (IHD), no large-scale epidemiological studies have shown a significant association between the two. To investigate the association between CO poisoning and IHD, a nested case-control study of 28,113 patients who experienced CO poisoning and 28,113 controls matched by sex and age was performed using the nationwide health database of South Korea. Based on a conditional logistic regression, there was a significantly higher risk of IHD among the CO poisoning group than among the control group (adjusted hazard ratio [HR], 2.16; 95% confidence interval [CI], 1.87-2.49). The risk of IHD after CO poisoning was higher among the younger age group under 40 years (adjusted HR, 4.85; 95% CI, 3.20-7.35), and it was much greater among those with comorbidities (adjusted HR, 10.69; 95% CI, 2.41-47.51). The risk of IHD was the highest within the first two years after CO poisoning (adjusted HR, 11.12; 95% CI, 4.54-27.22). Even if more than six years had passed, the risk was still significantly higher than among the control group (adjusted HR, 1.55; 95% CI, 1.27-1.89). The analyses imply that CO poisoning is associated with an increased risk of IHD.<p /> <p>Language: en</p>",
language="en",
issn="2305-6304",
doi="10.3390/toxics9100239",
url="http://dx.doi.org/10.3390/toxics9100239"
}