@article{ref1,
title="Sarcopenia and osteoporosis in older people: a systematic review and meta-analysis",
journal="European geriatric medicine",
year="2018",
author="Nielsen, Barbara Rubek and Abdulla, Jawdat and Andersen, Hanne Elkjær and Schwarz, Peter and Suetta, Charlotte",
volume="9",
number="4",
pages="419-434",
abstract="BACKGROUND: Age-related loss of muscle and bone (sarcopenia and osteoporosis), increases the risk of falls and fractures and consequently leads to a substantial economic burden for the society. The combined condition, osteosarcopenia, may identify patients at a higher risk of those outcomes and could be relevant for assessment and treatment in clinical practice. <br><br>AIM: To evaluate the current knowledge of the prevalence of osteosarcopenia and the fracture risk in older people. <br><br>METHOD: A systematic literature review was conducted until 10th March 2018. A total of 1105 papers were detected, whereof 1049 and 29 were excluded by title/abstracts and full-text assessment, respectively. Twenty-seven original papers were included in the systematic review, whereof 17 were suitable for meta-analysis. <br><br>RESULTS: The prevalence of osteosarcopenia varied (5-37%) depending on the classification of sarcopenia and whether participants were classified initially according to sarcopenia or osteoporosis. In patients with low-energy osteoporotic fractures, sarcopenia was present in 7.8-58% and 1.3-96.3% of the cases, women and men, respectively. The meta-analysis of prevalence of sarcopenia in patients with low-energy fracture (n = 9) was 46% (95% CI 44, 48; p < 0.001). The relative risk of fracture (sarcopenic versus non-sarcopenic) in meta-analysis of four studies was 1.37 (95% CI 1.18, 1.59; p < 0.001). Mean bone mineral density (n = 5) and T-score (n = 3) of femoral neck was significantly lower in sarcopenic participants [- 0.07 g/cm(2) (95% CI 0.08, 0.06) and - 0.34 (95% CI - 0.46, - 0.23), respectively]. <br><br>CONCLUSION: Osteosarcopenia is frequent and the relative risk of fracture is higher among sarcopenic patients. A standard and strict classification of sarcopenia is needed to assess its true relationship and consequences.<p /> <p>Language: en</p>",
language="en",
issn="1878-7649",
doi="10.1007/s41999-018-0079-6",
url="http://dx.doi.org/10.1007/s41999-018-0079-6"
}