@article{ref1,
title="Biomarkers of inflammation and inflammation-related indexes upon emergency department admission are predictive for the risk of intensive care unit hospitalization and mortality in acute poisoning: a 6-year prospective observational study",
journal="Disease markers",
year="2021",
author="Lionte, Catalina and Bologa, Cristina and Sorodoc, Victorita and Petris, Ovidiu Rusalim and Puha, Gabriela and Stoica, Alexandra and Ceasovschih, Alexandr and Jaba, Elisabeta and Sorodoc, Laurentiu",
volume="2021",
number="",
pages="e4696156-e4696156",
abstract="Patients poisoned with drugs and nonpharmaceutical substances are frequently admitted from the emergency department (ED) to a medical or ICU department. We hypothesized that biomarkers of inflammation and inflammation-related indexes based on the complete blood cell (CBC) count can identify acutely poisoned patients at increased risk for ICU hospitalization and death. We performed a 6-year prospective cohort study on 1548 adult patients. The demographic data, the levels of hs-CRP (high-sensitivity C-reactive protein), CBC, and inflammation-related indexes based on CBC counts were collected upon admission and compared between survivors and nonsurvivors, based on the poison involved. Both a multivariate logistic regression model with only significant univariate predictors and a model including univariate predictors plus each log-transformed inflammation-related indexes for mortality were constructed. The importance of the variables for mortality was graphically represented using the nomogram. hs-CRP (odds ratio (OR), 1.38; 95% CI, 1.16-1.65, p < 0.001 for log-transformed hs-CRP), red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) were significantly associated with the risk of ICU hospitalization, after multivariable adjustment. Only RDW, NLR, and monocyte-lymphocyte ratio (MLR) were significantly associated with mortality. The predictive accuracy for mortality of the models which included either NLR (AUC 0.917, 95% CI 0.886-0.948) or MLR (AUC 0.916, 95% CI 0.884-0.948) showed a high ability for prognostic detection. The use of hs-CRP, RDW, NLR, and MLR upon ED admission are promising screening tools for predicting the outcomes of patients acutely intoxicated with undifferentiated poisons.<p /> <p>Language: en</p>",
language="en",
issn="0278-0240",
doi="10.1155/2021/4696156",
url="http://dx.doi.org/10.1155/2021/4696156"
}