@article{ref1,
title="Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man",
journal="Journal of psychopharmacology",
year="2002",
author="Schmitt, Jeroen A. J. and Ramaekers, Johannes Gerardus and Kruizinga, Monique J. and van Boxtel, M. P. and Vuurman, E. F. and Riedel, Wim J.",
volume="16",
number="3",
pages="207-214",
abstract="There is evidence for a specific impairment of human vigilance following enhancement of serotonergic activity by antidepressant drugs. In the present study, we investigated the putative role of serotonergic-dopaminergic interactions in diminished vigilance by comparing the attentional effects of sertraline, a selective serotonin reuptake inhibitor (SSRI) with additional mild dopamine stimulating effects, with those of paroxetine, a SSRI without dopamine activity, using a placebo-controlled, double-blind, three-way cross-over design. Twenty-one (of 24) healthy middle-aged subjects completed the three treatment periods of 2 weeks in which sertraline (50 mg, days 1-7; 100 mg, days 8-14), paroxetine (20 mg, days 1-7; 40 mg, days 8-14) and placebo were administered. Vigilance (Mackworth Clock Test), selective (Stroop, Dichotic Listening) and divided attention (Dichotic Listening) were assessed at baseline and on days 7 and 14 of each treatment period. Selective and divided attention were unaffected by SSRI treatment. Subchronic administration of paroxetine impaired vigilance performance at each investigated dose. Sertraline did not produce a significant decline in vigilance performance, presumably due to its concomitant effects on dopamine activity, counteracting the negative effects of serotonin on dopamine neurotransmission. It is concluded that a serotonergically mediated reduction of dopamine activity plays an important role in the reduction of human vigilance following SSRI administration.<p /> <p>Language: en</p>",
language="en",
issn="0269-8811",
doi="",
url="http://dx.doi.org/"
}