@article{ref1,
title="Continuity of genetic risk for aggressive behavior across the life-course",
journal="Behavior genetics",
year="2021",
author="Van der Laan, Camiel M. and Morosoli-García, José J. and van de Weijer, Steve G. A. and Colodro-Conde, Lucia and Lupton, Michelle K. and Mitchell, Brittany L. and McAloney, Kerrie and Parker, Richard and Burns, Jane M. and Hickie, Ian B. and Pool, René and Hottenga, Jouke-Jan and Martin, Nicholas G. and Medland, Sarah E. and Nivard, Michel G. and Boomsma, Dorret I.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.<p /> <p>Language: en</p>",
language="en",
issn="0001-8244",
doi="10.1007/s10519-021-10076-6",
url="http://dx.doi.org/10.1007/s10519-021-10076-6"
}