@article{ref1,
title="A substantia innominata-midbrain circuit controls a general aggressive response",
journal="Neuron",
year="2021",
author="Zhu, Zhenggang and Ma, Qingqing and Miao, Lu and Yang, Hongbin and Pan, Lina and Li, Kaiyuan and Zeng, Ling-Hui and Zhang, Xiaoxing and Wu, Jintao and Hao, Sijia and Lin, Shen and Ma, Xiulin and Mai, Weihao and Feng, Xiang and Hao, Yizhe and Sun, Li and Duan, Shumin and Yu, Yan-Qin",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Although aggressive behaviors are universal and essential for survival, &quot;uncontrollable&quot; and abnormal aggressive behaviors in animals or humans may have severe adverse consequences or social costs. Neural circuits regulating specific forms of aggression under defined conditions have been described, but how brain circuits govern a general aggressive response remains unknown. Here, we found that posterior substantia innominata (pSI) neurons responded to several aggression-provoking cues with the graded activity of differential dynamics, predicting the aggressive state and the topography of aggression in mice. Activation of pSI neurons projecting to the periaqueductal gray (PAG) increased aggressive arousal and robustly initiated/promoted all the types of aggressive behavior examined in an activity-level-dependent manner. Inactivation of the pSI circuit largely blocked diverse aggressive behaviors but not mating. By encoding a general aggressive response, the pSI-PAG circuit universally drives multiple aggressive behaviors and may provide a potential target for alleviating human pathological aggression.<p /> <p>Language: en</p>",
language="en",
issn="0896-6273",
doi="10.1016/j.neuron.2021.03.002",
url="http://dx.doi.org/10.1016/j.neuron.2021.03.002"
}