@article{ref1,
title="Risk levels of herb-induced liver injury in Korea: from a meta-analysis",
journal="Integrative medicine research",
year="2021",
author="Lee, Nam-Hun and Lee, Ga-Young and Park, Chan-Ran and Kim, Sul-Ki and Ahn, Yo-Chan and Cho, Jung-Hyo and Son, Chang-Gue",
volume="10",
number="3",
pages="e100705-e100705",
abstract="BACKGROUND: As the use of herbal medicines increased worldwide, there has been concern about the risk of herb-induced liver injury (HILI). Many clinical studies have assessed the risk of HILI in Korea. <br><br>METHODS: Therefore, we conducted a meta-analysis of the incidence of HILI in Korea, by analyzing nine clinical studies. These involved 8625 participants (3274 males; 5351 females), including 436 outpatients (three studies) and 8189 inpatients (six studies). <br><br>RESULTS: As a result, the overall incidence of HILI in Korea was 0.49% (95% CI 0.33-0.74%), and it was 0.57% in males and 0.30% in females. We found a similar incidence of HILI in prospective (0.51%) and retrospective (0.50%) studies. The incidence of HILI was higher in inpatients (0.62%) than outpatients (0.03%). <br><br>CONCLUSION: Although there are limitations regarding study quality and the number of participants, we systematically estimated the risk of HILI in Korea. We anticipate this study would be a helpful information for prescribing herbal medicines and researching the safety of herbs.<p /> <p>Language: en</p>",
language="en",
issn="2213-4220",
doi="10.1016/j.imr.2020.100705",
url="http://dx.doi.org/10.1016/j.imr.2020.100705"
}