@article{ref1,
title="Longitudinal changes in blood-based biomarkers in chronic moderate to severe traumatic brain injury: preliminary findings",
journal="Brain injury",
year="2021",
author="Schnakers, Caroline and Divine, James and Johnson, Micah A. and Lutkenhoff, Evan and Monti, Martin M. and Keil, Katrina M. and Guthrie, John and Pouratian, Nader and Patterson, David and Jensen, Gary and Morales, Vanessa C. and Weaver, Kathleen F. and Rosario, Emily R.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVES: This longitudinal study aims at 1) providing preliminary evidence of changes in blood-based biomarkers across time in chronic TBI and 2) relating these changes to outcome measures and cerebral structure and activity. <br><br>METHODS: Eight patients with moderate-to-severe TBI (7 males, 35 ± 7.6 years old, 5 severe TBI, 17.52 ± 3.84 months post-injury) were evaluated at monthly intervals across 6 time-points using: a) Blood-based biomarkers (GFAP, NSE, S100A12, SDBP145, UCH-L1, T-tau, P-tau, P-tau/T-tau ratio); b) Magnetic Resonance Imaging to evaluate changes in brain structure; c) Resting-state electroencephalograms to evaluate changes in brain function; and d) Outcome measures to assess cognition, emotion, and functional recovery (MOCA, RBANS, BDI-II, and DRS). <br><br>RESULTS: Changes in P-tau levels were found across time [p = .007]. P-tau was positively related to functional [p < .001] and cognitive [p = .006] outcomes, and negatively related to the severity of depression, 6 months later [R = -0.901; p =.006]. P-tau and P-tau/T-tau ratio were also positively correlated to shape change in subcortical areas such as brainstem [T(7) = 4.71, p = .008] and putamen [T(7) = 3.25, p = .012]. <br><br>CONCLUSIONS: Our study provides preliminary findings that suggest a positive relationship between P-tau and the recovery of patients with chronic TBI.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2020.1858345",
url="http://dx.doi.org/10.1080/02699052.2020.1858345"
}