@article{ref1,
title="Efficacy of polyunsaturated fatty acids (PUFAs) on impulsive behaviours and aggressiveness in psychiatric disorders",
journal="International journal of molecular sciences",
year="2021",
author="Bellino, Silvio and Rocca, Paola and Mantelli, Emanuela and Badino, Cristina and Bozzatello, Paola",
volume="22",
number="2",
pages="e620-e620",
abstract="It is the focus of increasing interest to investigate the effects of long-chain n-3 and long-chain n-6 polyunsaturated fatty acids (LC n-3 PUFAs; LC n-6 PUFAs) on  psychiatric symptoms in a transdiagnostic perspective. There is some evidence that  low levels of LC n-3 PUFAs and a higher ratio of LC n-6 to LC n-3 PUFAs in plasma  and blood cells are associated with aggressive and impulsive behaviours. Therefore,  implementation of LC n-3 PUFAs may produce positive effects on hostility,  aggression, and impulsivity in both psychiatric and non-psychiatric samples across  different stages of life. A possible mechanism of action of LC n-3 PUFAs in  conditions characterized by a high level of impulsivity and aggression is due to the  effect of these compounds on the serotonin system and membrane stability. Studies  that evaluated the effects of LC n-3 PUFAs on impulsivity and aggressiveness  indicated that addition of rather low doses of these agents to antipsychotic  treatment might reduce agitation and violent behaviours in psychosis, attention  deficit hyperactivity disorder, personality disorders, and impulsive control and  conduct disorders. The present review is aimed at examining and discussing available  data from recent trials on this topic.<p /> <p>Language: en</p>",
language="en",
issn="1661-6596",
doi="10.3390/ijms22020620",
url="http://dx.doi.org/10.3390/ijms22020620"
}