@article{ref1,
title="Expression of GFAP and Tau following blast exposure in the cerebral cortex of ferrets",
journal="Journal of neuropathology and experimental neurology",
year="2021",
author="Juliano, Sharon L. and Perl, Daniel P. and McCabe, Joseph T. and Armstrong, Regina C. and Djankpa, Francis T. and Hutchinson, Elizabeth B. and Chatterjee, Mitali and Schwerin, Susan C.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Blast exposures are a hallmark of contemporary military conflicts. We need improved preclinical models of blast traumatic brain injury for translation of pharmaceutical  and therapeutic protocols. Compared with rodents, the ferret brain is larger, has  substantial sulci, gyri, a higher white to gray matter ratio, and the hippocampus in  a ventral position; these attributes facilitate comparison with the human brain. In  this study, ferrets received compressed air shock waves and subsequent evaluation of  glia and forms of tau following survival of up to 12 weeks. Immunohistochemistry and  Western blot demonstrated altered distributions of astrogliosis and tau expression  after blast exposure. Many aspects of the astrogliosis corresponded to human  pathology: increased subpial reactivity, gliosis at gray-white matter interfaces,  and extensive outlining of blood vessels. MRI analysis showed numerous  hypointensities occurring in the 12-week survival animals, appearing to correspond  to luminal expansions of blood vessels. Changes in forms of tau, including  phosphorylated tau, and the isoforms 3R and 4R were noted using immunohistochemistry  and Western blot in specific regions of the cerebral cortex. Of particular interest  were the 3R and 4R isoforms, which modified their ratio after blast. Our data  strongly support the ferret as an animal model with highly translational features to  study blast injury.<p /> <p>Language: en</p>",
language="en",
issn="0022-3069",
doi="10.1093/jnen/nlaa157",
url="http://dx.doi.org/10.1093/jnen/nlaa157"
}