@article{ref1,
title="A roadmap of brain recovery in a mouse model of concussion: insights from neuroimaging",
journal="Acta neuropathologica communications",
year="2021",
author="Nasrallah, Fatima A. and To, Xuan Vinh",
volume="9",
number="1",
pages="e2-e2",
abstract="Concussion or mild traumatic brain injury is the most common form of traumatic brain injury with potentially long-term consequences. Current objective diagnosis and  treatment options are limited to clinical assessment, cognitive rest, and symptom  management, which raises the real danger of concussed patients being released back  into activities where subsequent and cumulative injuries may cause disproportionate  damages. This study conducted a cross-sectional multi-modal examination  investigation of the temporal changes in behavioural and brain changes in a mouse  model of concussion using magnetic resonance imaging. Sham and concussed mice were  assessed at day 2, day 7, and day 14 post-sham or injury procedures following a  single concussion event for motor deficits, psychological symptoms with open field  assessment, T2-weighted structural imaging, diffusion tensor imaging (DTI), neurite  orientation density dispersion imaging (NODDI), stimulus-evoked and resting-state  functional magnetic resonance imaging (fMRI). Overall, a mismatch in the temporal  onsets and durations of the behavioural symptoms and structural/functional changes  in the brain was seen. Deficits in behaviour persisted until day 7 post-concussion  but recovered at day 14 post-concussion. DTI and NODDI changes were most extensive  at day 7 and persisted in some regions at day 14 post-concussion. A persistent  increase in connectivity was seen at day 2 and day 14 on rsfMRI. Stimulus-invoked  fMRI detected increased cortical activation at day 7 and 14 post-concussion. Our  results demonstrate the capabilities of advanced MRI in detecting the effects of a  single concussive impact in the brain, and highlight a mismatch in the onset and  temporal evolution of behaviour, structure, and function after a concussion. These  results have significant translational impact in developing methods for the  detection of human concussion and the time course of brain recovery.<p /> <p>Language: en</p>",
language="en",
issn="2051-5960",
doi="10.1186/s40478-020-01098-y",
url="http://dx.doi.org/10.1186/s40478-020-01098-y"
}