@article{ref1,
title="Characterizing the impact of adversity, abuse, and neglect on adolescent amygdala resting-state functional connectivity",
journal="Developmental cognitive neuroscience",
year="2020",
author="Cheng, Theresa W. and Mills, Kathryn L. and Miranda Dominguez, Oscar and Zeithamova, Dagmar and Perrone, Anders and Sturgeon, Darrick and Feldstein Ewing, Sarah W. and Fisher, Philip A. and Pfeifer, Jennifer H. and Fair, Damien A. and Mackiewicz Seghete, Kristen L.",
volume="47",
number="",
pages="e100894-e100894",
abstract="Characterizing typologies of childhood adversity may inform the development of risk profiles and corresponding interventions aimed at mitigating its lifelong  consequences. A neurobiological grounding of these typologies requires systematic  comparisons of neural structure and function among individuals with different  exposure histories. Using seed-to-whole brain analyses, this study examined  associations between childhood adversity and amygdala resting-state functional  connectivity (rs-fc) in adolescents aged 11-19 years across three independent  studies (N = 223; 127 adversity group) in both general and dimensional models of  adversity (comparing abuse and neglect). In a general model, adversity was  associated with altered amygdala rs-fc with clusters within the left anterior  lateral prefrontal cortex. In a dimensional model, abuse was associated with altered  amygdala rs-fc within the orbitofrontal cortex, dorsal precuneus, posterior  cingulate cortex, and dorsal anterior cingulate cortex/anterior mid-cingulate  cortex, as well as within the dorsal attention, visual, and somatomotor networks. Neglect was associated with altered amygdala rs-fc with the hippocampus,  supplementary motor cortex, temporoparietal junction, and regions within the dorsal  attention network. Both general and dimensional models revealed unique regions,  potentially reflecting pathways by which distinct histories of adversity may  influence adolescent behavior, cognition, and psychopathology.<p /> <p>Language: en</p>",
language="en",
issn="1878-9293",
doi="10.1016/j.dcn.2020.100894",
url="http://dx.doi.org/10.1016/j.dcn.2020.100894"
}