@article{ref1,
title="Symptom cluster profiles following traumatic orthopedic injuries: a protocol",
journal="Research in nursing and health",
year="2020",
author="Breazeale, Stephen and Dorsey, Susan G. and Kearney, Joan and Conley, Samantha and Jeon, Sangchoon and Yoo, Brad and Redeker, Nancy S.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Traumatic injuries affect millions of Americans annually, resulting in $671 billion  in healthcare costs and lost productivity. Postinjury symptoms, like pain, sleep  disturbance, anxiety, depression, and stressor-related disorders are highly  prevalent following traumatic orthopedic injuries (TOI) and may contribute to  negative long-term outcomes. Symptoms rarely present in isolation, but in clusters  of two or more symptoms that co-occur to affect health in aggregate. Identifying  symptom cluster profiles following TOI may identify those at highest risk for  negative outcomes. Dysregulation of brain-derived neurotrophic factor (BDNF) is a  potential biological mechanism responsible for symptom cluster profile membership  after TOI and may be targeted in future precision-health applications. The purpose  of this paper is to present the protocol of a cross-sectional study designed to  identify symptom cluster profiles and measure the extent to which the BDNF val66met  mutation and serum concentration of BDNF are associated with membership in symptom  cluster profiles. We plan to recruit 150 TOI survivors within the first 72 h of  injury. The study aims are to (1) describe TOI survivors' membership in symptom  cluster profiles, indicated by pain, sleep disturbance, and symptoms of anxiety,  depression, and stressor-related disorders, immediately following a TOI; (2) examine  associations between demographic and clinical factors and symptom cluster profile  membership among TOI survivors; (3) test the hypothesis that low serum  concentrations of BDNF are associated with membership among symptom cluster profiles  following TOI; and (4) test the hypothesis that the presence of the val66met  mutation on one or both alleles of the BDNF gene is associated with membership among  symptom cluster profiles following TOI.<p /> <p>Language: en</p>",
language="en",
issn="0160-6891",
doi="10.1002/nur.22102",
url="http://dx.doi.org/10.1002/nur.22102"
}