@article{ref1,
title="Fixation stability as a biomarker for differentiating mild traumatic brain injury from age matched controls in pediatrics",
journal="Brain injury",
year="2020",
author="Hunfalvay, Melissa and Murray, Nicholas P. and Carrick, Frederick Robert",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVES: Traumatic brain injury (TBI) is an increasingly significant health  concern worldwide, compounded by the difficultly in detection and diagnosis. Fortunately, a growing body of research has identified oculomotor behavior,  specifically fixations, saccades and smooth pursuit eye movements as a promising  endophenotype for neurotrauma. To date, limited research exists using fixation  stability in a comparative study to indicate the presence of a mild TBI (mTBI),  especially in the pediatric population. <br><br>METHODS: The present study examined data  from 91 individuals clinically diagnosed with mTBI and a further 140 age- and  gender-matched controls. They all completed the RightEye fixation stability test  using a remote eye tracker. Participants were compared on five fixation metrics:  Bivariate Contour Ellipse Area (BCEA), Convergence Point, Depth, Disassociated  Phoria, and Targeting Displacement. <br><br>RESULTS: Results were analyzed using one-way  univariate ANOVAs, ROC analysis, and stepwise logistic regression. BCEA results  revealed significant differences between groups with the mTBI group showing a larger  gaze spread, indicative of less ability to keep the eyes close to the target without  deviating. <br><br>CONCLUSIONS: Fixation stability is detrimentally impacted by mTBI in  pediatric patients, and the oculomotor test can be used to differentiate between  those with and without an mTBI.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2020.1865566",
url="http://dx.doi.org/10.1080/02699052.2020.1865566"
}