@article{ref1,
title="Concurrent and prospective associations of obsessive-compulsive symptoms with  suicidality in young adults: a genetically-informative study",
journal="Journal of affective disorders",
year="2020",
author="Krebs, Georgina and Mataix-Cols, David and Rijsdijk, Fruhling and Ruck, Christian and Lichtenstein, Paul and Lundström, Sebastian and Larsson, Henrik and Eley, Thalia C. and Fernández de la Cruz, Lorena",
volume="281",
number="",
pages="422-430",
abstract="BACKGROUND: Obsessive-compulsive disorder (OCD) has been linked with elevated risk  of suicidality. However, most previous studies have been cross-sectional, and little  is known about the aetiology of the association between obsessive-compulsive  symptoms (OCS) and suicidality in young adults. <br><br>METHODS: Participants were members  of the Child and Adolescent Twin Study in Sweden, at ages 18 (n = 9,162) and 24  (n = 3,466). Twins completed self-report measures, including assessment of OCS,  suicidal ideation, and suicidal attempts. Logistic regression models tested  concurrent and prospective associations of total OCS and OCS dimensions with  suicidality, with and without adjustment for depression and anxiety symptoms. Genetic models tested the extent to which the main phenotypic associations were  accounted for by genetic and environmental influences. <br><br>RESULTS: Total OCS were  significantly associated with concurrent reports of suicidality at age 18 and 24,  even when controlling for depressive and anxiety symptoms. Taboo obsessions (e.g.,  sexual and aggressive thoughts) were more robustly associated with suicidality than  other OCS dimensions, and prospectively predicted suicidality symptoms over time,  even when controlling for baseline suicide attempts. Genetic factors accounted for  most of the concurrent and longitudinal covariance between OCS and suicidality, with  substantial non-shared environmental influences. LIMITATIONS: We relied on  self-report measures and did not include diagnostic assessment of OCD. <br><br>CONCLUSIONS:  OCS, particularly taboo obsessions, are associated with significantly elevated risk  of suicidality in late adolescence and early adulthood. This relationship is  explained by a combination of common genetic liability and non-shared environmental  effects, suggesting that effective OCS treatment might reduce suicidality risk in  this group.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2020.10.065",
url="http://dx.doi.org/10.1016/j.jad.2020.10.065"
}