@article{ref1,
title="Investigating neurocognitive functioning in youths with externalizing disorders from the Philadelphia Neurodevelopmental Cohort",
journal="Journal of Adolescent Health",
year="2020",
author="Honrath, Philipp and Kohls, Gregor and Moore, Tyler M. and Dogan, Imis and Gur, Ruben C. and Habel, Ute and Konrad, Kerstin and Reetz, Kathrin and Gur, Raquel E.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="PURPOSE: Disruptive behavior disorders (DBD) and attention-deficit/hyperactivity disorder (ADHD) are externalizing disorders that frequently co-occur but also have distinct clinical characteristics. Identifying distinct neurocognitive phenotypes may help optimizing individual diagnosis and treatment of both disorders.   METHODS: Using data from 6,517 children and adolescents from the Philadelphia Neurodevelopmental Cohort, we investigated diagnostic group (i.e., typically developing, DBD, ADHD, DBD + ADHD) and sex differences across various neurocognitive functions, as well as co-occurring psychiatric symptoms, while adjusting for various confounding factors.   RESULTS: Neurocognitive deficits were associated with ADHD but not DBD. Co-occurring DBD in both girls and boys with ADHD did not appear to have an additive deteriorating effect on neurocognitive functioning. Task-specific sex differences were observed but did not interact with diagnostic group.   CONCLUSIONS: The findings of this study suggest that neurocognitive deficits in DBD seem to be largely driven by co-occurring ADHD and this applies equally to both sexes.<p /> <p>Language: en</p>",
language="en",
issn="1054-139X",
doi="10.1016/j.jadohealth.2020.10.029",
url="http://dx.doi.org/10.1016/j.jadohealth.2020.10.029"
}