@article{ref1,
title="Clinical features and mortality-related factors of extensive burns among young adults: the Kunshan disaster experience",
journal="Annals of translational medicine",
year="2020",
author="Huang, Ying-Zi and Lu, Guo-Zhong and Zhao, Hong-Sheng and Liu, Li-Jun and Jin, Jun and Wu, Yun-Fu and Wu, Jian and Zhao, Fu-Li and Liu, Ning and Liu, Wen-Ming and Liu, Long and Zhu, Tuan-Jie and Chen, Er-Zhen and Gu, Qin and Ye, Hong-Wei and Xi, Xiu-Ming and Du, Bin and Yi, Yang and Qiu, Hai-Bo",
volume="8",
number="17",
pages="e1053-e1053",
abstract="BACKGROUND: The aim of the study was to identify the clinical features and the factors associated with burn induced mortality among young adults after exposure to indoor explosion and fire.   Methods: This is an observational study which included burn patients who were admitted to eighteen ICUs after a fire disaster. Epidemiologic and clinical characteristics, as well as therapy were recorded. The primary outcome was 90-day mortality. The mortality-related factors were also analyzed.   Results: There were 167 burn patients enrolled in the study, the median age was 38 years, 62 (37.1%) patients died within 90 days. Seventy-one percent of patients had a burn size ≥90% TBSA, and 73.7% of patients had a full-thickness burn area above 50% TBSA. The survivors had lower Baux scores, and received earlier escharectomy and autologous skin grafts. The 50% mortality rates (LA50s) for burn size and full-thickness burn area were 95.8% and 88.6% TBSA, respectively. The multivariate analysis showed that full-thickness burn area over 50% TBSA and residual burned surface area (RBSA)/TBSA at 28 days were strong predictors of mortality among burn patients (odds ratio 2.55; 95% CI, 1.01 to 6.44, P=0.047; odds ratio 1.07; 95% CI, 1.04 to 1.09, P<0.001). The ROC curve-based cut-off values of RBSA/TBSA at 28 days for predicting 90-day mortality were 62.5%.   Conclusions: Burn size and full-thickness burn area were the main risk factors for poor outcome in patients with extensive burns. Earlier escharectomy and autologous skin grafts may improve outcomes.<p /> <p>Language: en</p>",
language="en",
issn="2305-5839",
doi="10.21037/atm-20-288",
url="http://dx.doi.org/10.21037/atm-20-288"
}