@article{ref1,
title="Vitamin D supplementation: upper limit for safety revisited?",
journal="Aging clinical and experimental research",
year="2020",
author="Rizzoli, René",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, but on the outcome, the treatment regimen, and possibly the age, sex and vitamin D status. The therapeutic window of vitamin D supplementation may be narrower than hitherto recognized. The prevention and/or correction of vitamin D deficiency/insufficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected.<p /> <p>Language: en</p>",
language="en",
issn="1594-0667",
doi="10.1007/s40520-020-01678-x",
url="http://dx.doi.org/10.1007/s40520-020-01678-x"
}