@article{ref1,
title="Immune to happiness - inflammatory process indicators and depressive personality traits",
journal="Archives of medical science",
year="2020",
author="Talarowska, Monika E. and Kowalczyk, Małgorzata and Maes, Michael and Carvalho, Andre and Su, Kuan-Pin and Szemraj, Janusz and Gałecki, Piotr",
volume="16",
number="4",
pages="848-857",
abstract="INTRODUCTION: Nowadays, depression is conceptualized as an immune-inflammatory and oxidative stress disorder associated with neuroprogressive changes as a consequence of peripherally activated immune-inflammatory pathways, including peripheral cytokines and immune cells which penetrate into the brain via the blood barrier, as well as nitro-oxidative stress and antioxidant imbalances. The aim of this study was to investigate whether personality traits predisposing to a depressive episode (hypochondria, dysthymic, hysteria) are associated with changes in peripheral gene expression for selected indicators of inflammation and oxidative balance.   Material and methods: One hundred four people meeting the diagnostic criteria specified for a depressive episode took part in the study. Selected scales of the Minnesota Multiphasic Personality Inventory (MMPI-2) were used to measure personality traits. Expression at the mRNA and protein level for manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), and metalloproteinases 2 and 9 (MMP-2, MMP-9) was examined.   Results: Scales for the neurotic triad of the MMPI-2 test correlated significantly with the expression at the level of mRNA and protein for MnSOD, MPO and metalloproteinases 2 and 9.   Conclusions: The scales specified for the neurotic triad of the MMPI-2 test correspond substantially with the expression of MnSOD, MPO and metalloproteinases 2 and 9 at the mRNA and protein levels in the group of patients suffering from depression.<p /> <p>Language: en</p>",
language="en",
issn="1734-1922",
doi="10.5114/aoms.2019.83146",
url="http://dx.doi.org/10.5114/aoms.2019.83146"
}