@article{ref1,
title="The prevalence and stability of sleep-wake disturbance and fatigue throughout the first year after mild traumatic brain injury",
journal="Journal of neurotrauma",
year="2020",
author="Saksvik, Simen B. and Karaliute, Migle and Kallestad, Håvard and Follestad, Turid and Asarnow, Robert F. and Vik, Anne and Håberg, Asta Kristine and Skandsen, Toril and Olsen, Alexander",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="In this prospective longitudinal study, we aimed to determine the prevalence and stability of sleep-wake disturbance and fatigue in a large representative sample of patients (Trondheim mTBI follow-up study). We included 378 patients with mTBI (age 16-60), 82 matched trauma controls with orthopedic injuries, and 83 matched community controls. Increased sleep need, poor sleep quality, excessive daytime sleepiness and fatigue were assessed at two weeks, three months and 12 months after injury. Mixed logistic regression models were used to evaluate clinically relevant group differences longitudinally. The prevalence of increased sleep need, poor sleep quality and fatigue was significantly higher in patients with mTBI than in both trauma controls and community controls at all time points. More patients with mTBI reported problems with excessive daytime sleepiness compared to trauma controls, but not community controls, at all time points. Patients with complicated mTBI (intracranial findings on CT or MRI) had more fatigue problems compared to those with uncomplicated mTBI, at all three time points. In patients with mTBI who experienced sleep-wake disturbances and fatigue two weeks after injury, about half still had problems at three months and about one third at 12 months. Interestingly, we observed limited overlap between the different symptom measures; a large number of patients reported one specific problem with sleep-wake disturbance or fatigue rather than several problems. In conclusion, our results provide strong evidence that mTBI contributes significantly to the development and maintenance of sleep-wake disturbances and fatigue.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2019.6898",
url="http://dx.doi.org/10.1089/neu.2019.6898"
}