@article{ref1,
title="Sex differences in brain gene expression among suicide completers",
journal="Journal of affective disorders",
year="2020",
author="Cabrera-Mendoza, Brenda and Fresno, Cristobal and Monroy-Jaramillo, Nancy and Fries, Gabriel Rodrigo and Walss-Bass, Consuelo and Glahn, David C. and Ostrosky-Wegman, Patricia and Mendoza-Morales, Roberto Cuauhtemoc and Garcia-Dolores, Fernando and Díaz-Otañez, Carlos Enrique and González-Sáenz, Eli Elier and Genis-Mendoza, Alma Delia and Martinez-Magaña, Jose Jaime and Romero-Pimentel, Ana Luisa and Flores, Gonzalo and Vázquez-Roque, Rubén Antonio and Nicolini, Humberto",
volume="267",
number="",
pages="67-77",
abstract="BACKGROUND: Suicide rates vary substantially by sex. Suicides committed by males significantly outnumber female suicides. Disparities in community and social factors provide a partial explanation for this phenomenon. Thus, the evaluation of sex differences at a biological level might contribute to the elucidation of the factors involved in this imbalance. The aim of the present study was to evaluate sex-specific gene expression patterns in the suicidal brain. <br><br>METHODS: postmortem samples from the dorsolateral prefrontal cortex (DLPFC) of 75 Latino individuals were analyzed. We considered the following groups: i) male suicides (n = 38), ii) female suicides (n = 10), iii) male controls (n = 20), and iv) female controls (n = 7). Gene expression profiles were evaluated by microarrays. Differentially expressed genes among the groups were identified with a linear model. Similarities and differences in the gene sets between the sexes were identified. <br><br>RESULTS: Differentially expressed genes were identified between suicides and controls of each sex: 1,729 genes in females and 1,997 genes in males. Female-exclusive suicide genes were related to cell proliferation and immune response. Meanwhile, male-exclusive suicide genes were associated to DNA binding and ribonucleic protein complex. Sex-independent suicide genes showed enrichment in mitochondrial and vesicular functions. LIMITATIONS: Relatively small sample size. Our diagnosis approach was limited to information found on coroner's records. The analysis was limited to a single brain area (DLPFC) and we used microarrays. <br><br>CONCLUSION: Previously unexplored sex differences in the brain gene expression of suicide completers were identified, providing valuable foundation for the evaluation of sex-specific factors in suicide.<br><br>Copyright © 2020 Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2020.01.167",
url="http://dx.doi.org/10.1016/j.jad.2020.01.167"
}