@article{ref1,
title="A model of longitudinal hemodynamic alterations after mild traumatic brain injury in adolescents",
journal="Journal of concussion",
year="2019",
author="Thibeault, Corey M. and Thorpe, Samuel and Canac, Nicolas and O'Brien, Michael J. and Ranjbaran, Mina and Wilk, Seth J. and Hamilton, Robert B.",
volume="3",
number="",
pages="e2059700219838654-e2059700219838654",
abstract="There is an unquestionable need for quantitative biomarkers of mild traumatic brain injuries. Something that is particularly true for adolescents - where the recovery from these injuries is still poorly understood. However, within this population, it is clear that the vasculature is distinctly affected by a mild traumatic brain injury. In addition, our group recently demonstrated how that effect appears to show a progression of alterations similar but in contrast to that found in severe traumatic injuries. Through measuring an adolescent population with transcranial Doppler ultrasound during a hypercapnia challenge, multiple phases of hemodynamic dysfunction were suggested. Here, we create a generalized model of the hemodynamic responses by fitting a set of inverse models to the dominant features from that work. The resulting model helps define the multiple phases of hemodynamic recovery after a mild traumatic brain injury. This can eventually be generalized, potentially providing a diagnostic tool for clinicians tracking patient's recovery, and ultimately, resulting in more informed decisions and better outcomes.<p /> <p>Language: en</p>",
language="en",
issn="2059-7002",
doi="10.1177/2059700219838654",
url="http://dx.doi.org/10.1177/2059700219838654"
}