@article{ref1,
title="Parvalbumin promoter methylation altered in major depressive disorder",
journal="International journal of medical sciences",
year="2019",
author="Thaweethee-Sukjai, Benjamard and Suttajit, Sirijit and Thanoi, Samur and Dalton, Caroline F. and Reynolds, Gavin P. and Nudmamud-Thanoi, Sutisa",
volume="16",
number="9",
pages="1207-1214",
abstract="<b>Aims:</b> To determine the extent of DNA methylation of parvalbumin gene <i>(PVALB)</i> promoter in major depressive disorder (MDD) patients with and without suicide attempt in comparison with healthy controls. <b>Methods:</b> The extracted DNA from dried blood spots of MDD patients (n = 92) including non-suicidal MDD and suicidal-MDD subgroups (n = 45 and n = 47, respectively) and age-matched control subjects (n = 95) was used for DNA methylation analysis at four CpG sites in the promoter sequence of <i>PVALB</i> by pyrosequencing. <b>Results:</b> The <i>PVALB</i> methylation was significantly increased at CpG2 and decreased at CpG4 in the MDD group compared to the control group, while there was no difference between non-suicidal MDD and suicidal-MDD subgroups. A significant inverse correlation of severity of MDD was indicated only for CpG4. <b>Conclusion:</b> This study provides the first evidence of abnormalities of <i>PVALB</i> promoter methylation in MDD and its correlation with MDD severity indicating a role for epigenetics in this psychiatric disorder.<br><br>© The author(s).<p /> <p>Language: en</p>",
language="en",
issn="1449-1907",
doi="10.7150/ijms.36131",
url="http://dx.doi.org/10.7150/ijms.36131"
}