@article{ref1,
title="The Fall Risk with Alpha blockers Given InitiaL dose or Elderly status (FRAGILE) study",
journal="Annals of pharmacotherapy",
year="2019",
author="McDonnell, Chelsea C. and Rogers, Kelly C. and Regen, Sloan M. and Finks, Shannon W.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="<b>Background:</b> α-1 adrenergic antagonists are commonly prescribed, but there is question regarding their safety in patients at increased fall risk. <b>Objective:</b> The purpose of the FRAGILE study was to determine the risk for developing adverse drug events (ADEs) in veterans prescribed α-1 blockers. <b>Methods:</b> A single-center, retrospective, observational cohort analysis was conducted of veterans newly initiated on α-1 antagonists. Veterans were categorized into at-risk (patients who met at least 1 of 2 criteria: age 65 or older or high initial dose of α blockade) or control (veterans without either risk factor) groups. The primary outcome was the composite all-cause ADEs, including hospitalizations or emergency department (ED) visits. Secondary outcomes included number of fall-related ADEs and medication discontinuation rates with follow-up for 12 months. <b>Results:</b> A total of 300 veterans were evaluated. There was no significant difference in the composite outcome of all-cause ED visits between at-risk (n = 169) versus control (n = 131) groups (0.81 vs 1.17, <i>P</i> = 0.09) or all-cause hospitalizations (0.28 vs 0.39, <i>P</i> = 0.25). Seventy-three veterans in the at-risk group experienced an all-cause ADE versus 64 in the control group (<i>P</i> = 0.36). No significant differences in secondary outcomes were found. Fall-related side effects occurred in 8% of the total cohort. <b>Conclusion and Relevance:</b> Rates of all-cause or fall-related ADEs were not significantly different. An 8% discontinuation rate resulting from fall-related ADEs and high rates of coadministered medications that could increase fall risk. Pharmacists can play a key role in optimizing α-1 blocker administration.<p /> <p>Language: en</p>",
language="en",
issn="1060-0280",
doi="10.1177/1060028019880305",
url="http://dx.doi.org/10.1177/1060028019880305"
}