@article{ref1,
title="Severe acquired brain injury aetiologies, early clinical factors, and rehabilitation outcomes: a retrospective study on pediatric patients in rehabilitation",
journal="Brain injury",
year="2019",
author="Pozzi, Marco and Galbiati, Sara and Locatelli, Federica and Carnovale, Carla and Gentili, Marta and Radice, Sonia and Strazzer, Sandra and Clementi, Emilio",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="<b>Objective</b>: Studies on pediatric severe acquired brain injury (sABI) outcomes focused mostly on single etiologies, not clarifying the independent role of clinical factors, and scantly explored inter-dependence between variables. We assessed associations of clinical factors at admission with essential outcomes, controlling for inter-dependence and sABI etiology. <b>Methods</b>: We reviewed the clinical records of 280 patients with traumatic and 292 with non-traumatic sABI, discharged from intensive care to pediatric neurological rehabilitation. We analyzed the distribution of clinical factors based on sABI etiology; conducted a factor analysis of variables; built multivariate models evaluating the associations of variables with death, persistent vegetative states, duration of coma, GOS outcome, length of stay. <b>Results</b>: We described the study sample. Factor analysis of inter-dependence between GCS, time before rehabilitation, dysautonomia, device use, produced the indicators &quot;injury severity&quot; and &quot;neurological dysfunction&quot;, independent from sABI etiology, age, sex, and admittance GOS. Multivariate analyzes showed that: coma duration, GOS outcome, and length of stay, which may depend on rehabilitation courses, were directly associated with injury severity, neurological dysfunction, and patients' age; death and persistent vegetative states were also associated with etiology. <b>Conclusion</b>: Future studies should analyze larger cohorts and investigate mechanisms linking specific etiologies and patients' age with outcomes.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2019.1658128",
url="http://dx.doi.org/10.1080/02699052.2019.1658128"
}