@article{ref1,
title="Why exercise may be beneficial in concussion rehabilitation: a cellular perspective",
journal="Journal of science and medicine in sport",
year="2019",
author="Dech, Ryan T. and Bishop, Scott A. and Neary, J. Patrick",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="INTRODUCTION: Concussion diagnosis and rehabilitation management has become a prevalent area of research, and yet much is still unknown about these complex injuries. Historically, exercise prescription post-concussion was conservatively used for rehabilitation due to the suspected harmful effects that exercise can have on damaged neurons, and increase in symptoms. However, there has been a shift to implement exercise earlier into recovery as several studies have demonstrated positive outcomes. <br><br>OBJECTIVE: The objective of this literature review is to update the reader about new advances in concussion research related to the beneficial effects of physical activity from both a neurometabolic and a broader physiological perspective, using gene expression as a vehicle to demonstrate why and how physical activity has the capacity to optimize recovery from a cellular perspective. To further this clinical guideline, the evidence must continue to support these positive outcomes from an inductive and deductive physiologic approach (i.e., the clinical evidence aligned from a micro- to macroscopic approach and vice versa). <br><br>DESIGN: Narrative review. <br><br>METHODS: Pubmed and Medline were used with the following key words: concussion and, physical activity, neurometabolic, gene regulation, trauma, nervous system, mild head injury, acute exercise, cellular physiology and pathophysiology. <br><br>CONCLUSION: It is our contention that understanding the cellular perspective will help guide clinical management, and promote research into post-concussion exercise.<br><br>Copyright © 2019 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1440-2440",
doi="10.1016/j.jsams.2019.06.007",
url="http://dx.doi.org/10.1016/j.jsams.2019.06.007"
}