@article{ref1,
title="Significance of cardiac troponin I elevation in traumatic brain injury patients",
journal="Anesthesiology and pain medicine",
year="2019",
author="Rimaz, Siamak and Ashraf, Ali and Marzban, Shideh and Haghighi, Mohammad and Zia Ziabari, Seyyed Mahdi and Biazar, Gelareh and Rimaz, Sheyda and Omidi, Samad",
volume="9",
number="2",
pages="e90858-e90858",
abstract="BACKGROUND: Myocardial dysfunction is frequently described as an underlying cause of mortality in traumatic brain injury (TBI) known as brain-cardiac link. However the impact on prognosis of a disease remains uncertain. <br><br>OBJECTIVES: The current study aimed at investigating the correlation between TBI and cardiac troponin I (cTnI) rise and in-hospital mortality rate among patients with TBI. <br><br>METHODS: In the current prospective study TBI patients with abbreviated injury scale score (AIS) > 3 and Glasgow coma scale (GCS) score ≤ 8 with cTnI measurement within the first 24 hours of admission were evaluated. Chi-square, Kruskal-Wallis, Mann-Whitney U and Logistic Regression tests were used for data analysis. <br><br>RESULTS: A total of 166 eligible patients were studied.The mean age of the cases was 37.64 ± 17.21 years, largely under 65 (93.4%) and male (86.7%).The most common injuries were cerebral contusion (35.1%), while motor vehicle crash (MVC) was the most common cause of injuries (83.73%); 59 % of the patients showed detectable cTnI concentrations within 24 hours of admission; 65.7% of the patients expired; they showed higher levels of cTnI compared to survivors that showed lower levels, 0.148 ± 0.074 vs 0.057 ± 0.055, respectively (P < 0.001). Moreover, a significant association was observed between mortality rate and lower admission GCS 3.49 ± 1.08 vs 6.79 ± 1.66, respectively (P < 0.001). <br><br>CONCLUSIONS: Increased cTnI levels could be a predictor of mortality among patients with TBI. Its measurement and investigation for therapeutic strategies could lead to better management of these cases.<p /> <p>Language: en</p>",
language="en",
issn="2228-7523",
doi="10.5812/aapm.90858",
url="http://dx.doi.org/10.5812/aapm.90858"
}