@article{ref1,
title="Prenatal polybrominated diphenyl ether exposures and neurodevelopment in U.S. children through 5 years of age: the HOME study",
journal="Environmental health perspectives",
year="2014",
author="Chen, Aimin and Yolton, Kimberly and Rauch, Stephen A. and Webster, Glenys M. and Hornung, Richard and Sjödin, Andreas and Dietrich, Kim N. and Lanphear, Bruce P.",
volume="122",
number="8",
pages="856-862",
abstract="BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades. <br><br>OBJECTIVE: We examined whether in utero exposure to PBDEs is associated with child cognitive function and behavior in a U.S. study sample. <br><br>METHODS: In a prospective birth cohort, we measured maternal serum concentrations of BDE-47 and other PBDE congeners in 309 women at 16 weeks of gestation during 2003-2006 and followed their children in Cincinnati, Ohio. We measured cognitive and motor abilities using the Bayley Scales of Infant Development-II at ages 1, 2, and 3 years; intelligence using the Wechsler Preschool and Primary Scale of Intelligence-III at age 5 years; and children's behaviors using the Behavioral Assessment System for Children-2 annually at ages 2-5 years. We used linear mixed models or generalized estimating equations with adjustment for potential confounders to estimate associations between these outcomes and log10-transformed PBDE concentrations. <br><br>RESULTS: The geometric mean of BDE-47 in maternal serum (20.1 ng/g lipid) was comparable with U.S. adult national reference values. Prenatal BDE-47 was not significantly associated with Bayley Mental or Psychomotor Development Indices at 1-3 years, but a 10-fold increase in prenatal BDE-47 was associated with a 4.5-point decrease (95% CI: -8.8, -0.1) in Full-Scale IQ and a 3.3-point increase (95% CI: 0.3, 6.3) in the hyperactivity score at age 5 years. <br><br>CONCLUSIONS: Prenatal exposure to PBDEs was associated with lower IQ and higher hyperactivity scores in children.<p /><p>Language: en</p>",
language="en",
issn="0091-6765",
doi="10.1289/ehp.1307562",
url="http://dx.doi.org/10.1289/ehp.1307562"
}