@article{ref1,
title="The role of TaqI DRD2 (rs1800497) and DRD4 VNTR polymorphisms in posttraumatic stress disorder (PTSD)",
journal="Psychiatria Danubina",
year="2019",
author="Hoxha, Blerina and Goçi Uka, Afërdita and Agani, Ferid and Haxhibeqiri, Shpend and Haxhibeqiri, Valdete and Sabic Dzananovic, Emina and Kučukalić, Sabina and Bravo Mehmedbasic, Alma and Kucukalic, Abdulah and Dzubur Kulenovic, Alma and Feric Bojic, Elma and Marjanovic, Damir and Kravic, Nermina and Avdibegovic, Esmina and Muminovic Umihanić, Mirnesa and Jakšić, Nenad and Cima Franc, Ana and Rudan, Dusko and Jakovljević, Miro and Babić, Romana and Pavlović, Marko and Babic, Dragan and Aukst Margetić, Branka and Bozina, Nada and Sinanovic, Osman and Ziegler, Christiane and Warrings, Bodo and Domschke, Katharina and Deckert, Jürgen and Wolf, Christiane and Vyshka, Gentian",
volume="31",
number="2",
pages="263-268",
abstract="BACKGROUND: Posttraumatic stress disorder (PTSD) is a complex stress related disorder, that follows a severe traumatic experience, characterized with an intense sense of terror, fear, and helplessness. The aim of this study is to identify associations of genetic variations within candidate genes DRD2 and DRD4 with various PTSD related phenotypes. PTSD lifetime and PTSD current subjects were analyzed separately, each of them were analyzed in a Case/Control design, as well as regarding BSI and CAPS within cases only. <br><br>SUBJECTS AND METHODS: 719 (487 male, 232 female) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Hercegovina, Kosovo and Croatia were included in the study. Sociodemographic questionnaire, Clinician Administered PTSD Scale (CAPS) and the Brief Symptom Inventory (BSI) were used to collect clinical data. <br><br>RESULTS: The DRD2 rs1800497 variant and a variable number tandem repeat (VNTR) located in exon three of DRD4 were investigated for association with PTSD. In case control analyses we did not identify any significant associations. Within the PTSD current patients, we identified an association of DRD2 rs1800497 with BSI in the genotypic and the recessive model with the T allele as the risk allele. <br><br>CONCLUSION: Our findings suggest that rs1800497 of DRD2 gene is involved in pathogenesis of PTSD.<p /> <p>Language: en</p>",
language="en",
issn="0353-5053",
doi="10.24869/psyd.2019.263",
url="http://dx.doi.org/10.24869/psyd.2019.263"
}