@article{ref1,
title="Modelling the influence of age on neurologic outcome and quality of life one year after traumatic brain injury: a prospective multicenter cohort study",
journal="Journal of neurotrauma",
year="2019",
author="Bouzat, Pierre and Ageron, François-Xavier and Thomas, Marine and Vallot, Cecile and Hautefeuille, Serge and Schilte, Clotilde and Payen, Jean-François",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="After traumatic brain injury (TBI), the relationship between age and outcome at one-year, including quality of life, has been poorly explored. The aim of our study was to describe this relationship in a cohort of TBI patients in a regional trauma system. Consecutive TBI patients with severe lesions on initial brain CT scan were included from July 2014 to July 2016 in two French level-I trauma centers. The primary outcome was the mortality at one-year and secondary outcomes were Extended-Glasgow Outcome Scale (GOS-E) and quality of life using the Short Form health survey (SF-12). The relationship between age and outcome was modelled using generalized linear model (GLM). Within the study period, 427 patients with TBI and type-3 abbreviated injury score lesions were included. Finally, 380 patients were assessed for mortality. Ninety-six (25%) patients died at one year. The detailed neurologic status was available for 317 patients. One year after the trauma, 141 (44%) patients had favorable outcome (GOS-E 7 and 8) while 53 (17%) patients had moderate disability (GOS-E 5-6), 27 (9%) patients had severe disability or vegetative state (GOS-E 2-4) and 96 (30%) patients died (GOS-E 1). After 70-year-old, a dramatic increase in the odds of death and poor neurologic outcome was found using GLM. No difference according to age was found for the quality of life. After TBI, the mortality at one year dramatically increased with age after 70 years. For elderly survivors, impairment of quality of life was not different from younger patients.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2019.6432",
url="http://dx.doi.org/10.1089/neu.2019.6432"
}