@article{ref1,
title="Reduced default mode network functional connectivity in patients with recurrent major depressive disorder",
journal="Proceedings of the National Academy of Sciences of the United States of America",
year="2019",
author="Yan, Chao-Gan and Chen, Xiao and Li, Le and Castellanos, Francisco Xavier and Bai, Tong-Jian and Bo, Qi-Jing and Cao, Jun and Chen, Guan-Mao and Chen, Ning-Xuan and Chen, Wei and Cheng, Chang and Cheng, Yu-Qi and Cui, Xi-Long and Duan, Jia and Fang, Yi-Ru and Gong, Qi-Yong and Guo, Wen-Bin and Hou, Zheng-Hua and Hu, Lan and Kuang, Li and Li, Feng and Li, Kai-Ming and Li, Tao and Liu, Yan-Song and Liu, Zhe-Ning and Long, Yi-Cheng and Luo, Qing-Hua and Meng, Hua-Qing and Peng, Dai-Hui and Qiu, Hai-Tang and Qiu, Jiang and Shen, Yue-di and Shi, Yu-Shu and Wang, Chuan-Yue and Wang, Fei and Wang, Kai and Wang, Li and Wang, Xiang and Wang, Ying and Wu, Xiao-Ping and Wu, Xin-Ran and Xie, Chun-Ming and Xie, Guang-Rong and Xie, Hai-Yan and Xie, Peng and Xu, Xiu-Feng and Yang, Hong and Yang, Jian and Yao, Jia-Shu and Yao, Shu-Qiao and Yin, Ying-Ying and Yuan, Yong-Gui and Zhang, Ai-Xia and Zhang, Hong and Zhang, Ke-Rang and Zhang, Lei and Zhang, Zhi-Jun and Zhou, Ru-Bai and Zhou, Yi-Ting and Zhu, Jun-Juan and Zou, Chao-Jie and Si, Tian-Mei and Zuo, Xi-Nian and Zhao, Jing-Ping and Zang, Yu-Feng",
volume="116",
number="18",
pages="9078-9083",
abstract="Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol before aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion. We found FC reduction only in recurrent MDD, not in first-episode drug-naïve MDD. Decreased DMN FC was associated with medication usage but not with MDD duration. DMN FC was also positively related to symptom severity but only in recurrent MDD. Exploratory analyses also revealed alterations in FC of visual, sensory-motor, and dorsal attention networks in MDD. We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates response to treatment. All R-fMRI indices of data contributed by the REST-meta-MDD consortium are being shared publicly via the R-fMRI Maps Project.<br><br>Copyright © 2019 the Author(s). Published by PNAS.<p /> <p>Language: en</p>",
language="en",
issn="0027-8424",
doi="10.1073/pnas.1900390116",
url="http://dx.doi.org/10.1073/pnas.1900390116"
}