@article{ref1,
title="Single mild traumatic brain injury deteriorates progressive inter-hemispheric functional and structural connectivity",
journal="Journal of neurotrauma",
year="2019",
author="Wang, Zhuonan and Zhang, Ming and Sun, Chuanzhu and Wang, Shan and Cao, Jieli and Wang, Kevin K. W. and Gan, Shuoqiu and Huang, Wenmin and Niu, Xuan and Zhu, Yanan and Sun, Yingxiang and Bai, Lijun",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="The present study aims to examine dynamic inter-hemispheric structural and functional connectivity in mild traumatic brain injury (mTBI) patients with longitudinal observations from early sub-acute to chronic stages within one year. 42 mTBI patients and 42 matched healthy controls underwent clinical and neuropsychological evaluations as well as both diffusion tensor imaging (DTI) and resting state functional MRI scanning. All of the patients were initially evaluated within 14 days post-injury (T-1) and follow-up at 3 months (T-2) and 6-12 months (T-3). Separate trans-callosal fiber tracts in the corpus callosum (CC) with respect to their specific inter-hemispheric cortical projections were derived with analyses of fiber tracking and voxel mirrored homotopic connectivity (VMHC). With DTI-based tractography, we distinguished five vertical segments of the CC (I to V). Correlation analyses were performed to evaluate relationships between the structural and functional imaging measures as well as imaging indices and neuropsychological measures. The loss of integrity in the CC demonstrated saliently persistent and time-dependent regional specificity after mTBI. The impairment spanned multiple segments from the original CC II at T-1, CC I, II, VI, V at T-2 to all sub-regions at T-3. Moreover, loss inter-hemispheric structural connectivity through the CC corresponded well to regions presenting altered inter-hemispheric functional connectivity. The decreased functional connectivity in the dorsolateral prefrontal cortex thereafter contributed to the poor outcome of executive function in patients. The current study provides further evidence that CC was a sign to the inter-hemispheric highways underpinning the widespread cerebral pathology that typified the syndrome of mTBI.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2018.6196",
url="http://dx.doi.org/10.1089/neu.2018.6196"
}