@article{ref1,
title="Resting-state amplitude of low-frequency fluctuation is associated with suicidal ideation",
journal="Depression and anxiety",
year="2019",
author="Lan, Martin J. and Rizk, Mina M. and Pantazatos, Spiro P. and Rubin-Falcone, Harry and Miller, Jeffrey M. and Sublette, M. Elizabeth and Oquendo, Maria A. and Keilp, John G. and Mann, J. John",
volume="36",
number="5",
pages="433-441",
abstract="BACKGROUND: Identifying brain activity patterns that are associated with suicidal ideation (SI) may help to elucidate its pathogenesis and etiology. Suicide poses a significant public health problem, and SI is a risk factor for suicidal behavior. <br><br>METHODS: Forty-one unmedicated adult participants in a major depressive episode (MDE), 26 with SI on the Beck Scale for Suicidal Ideation and 15 without SI, underwent resting-state functional magnetic resonance imaging scanning. Twenty-one healthy volunteers (HVs) were scanned for secondary analyses. Whole brain analysis of both amplitude of low-frequency fluctuations (ALFFs) and fractional ALFF was performed in MDE subjects to identify regions where activity was associated with SI. <br><br>RESULTS: Subjects with SI had greater ALFF than those without SI in two clusters: one in the right hippocampus and one in the thalamus and caudate, bilaterally. Multi-voxel pattern analysis distinguished between those with and without SI. Post hoc analysis of the mean ALFF in the hippocampus cluster found it to be associated with a delayed recall on the Buschke memory task. Mean ALFF from the significant clusters was not associated with depression severity and did not differ between MDE and HV groups. <br><br>DISCUSSION: These results indicate that SI is associated with altered resting-state brain activity. The pattern of elevated activity in the hippocampus may be related to how memories are processed.<br><br>© 2019 Wiley Periodicals, Inc.<p /> <p>Language: en</p>",
language="en",
issn="1091-4269",
doi="10.1002/da.22888",
url="http://dx.doi.org/10.1002/da.22888"
}