@article{ref1,
title="Revisit of a rare death by overdosed midazolam: a forensic pathological perspective",
journal="Journal of forensic medicine (2016)",
year="2018",
author="Wang, John Z. and Wang, Liming",
volume="3",
number="1",
pages="e121-e121",
abstract="Midazolam has long been employed for sedation and analgesia purposes in medical surgeries. However, this case re-evaluation reports a rare death case by overdosed midazolam to demonstrate a complex murder plot in Dalian, China. Specifically, this research project analyses and re-evaluates the original investigation report, the original autopsy report and the examiners' findings. Based on the case analysis, the pathological examination indicates that a high concentration of midazolam (9.73 μg/ml) was tested in six needle mark areas (on the left arm and left/right buttock areas). The concentrations were determined and confirmed by LC/MS and GC/MS. This rare case strongly suggests that overdosed midazolam can be intravenously administered as a means of criminal homicide. This case was considered to be the first case reported by the forensic medicine community in China, which might indicate that overdosed midazolam may indicate a new means of killing in years to come. This research project may suggest three practical implications from a forensic pathological perspective. First, this analysis serves as a warning to the medical community that midazolam may have a dangerous side effect, if improperly administered. Second, several reports have indicated that overdosed midazolam can cause deaths. Finally, there has been a real case reported in China where overdosed midazolam was used to kill in a murder case with a concentration of midazolam (9.73 μg/ml) found in muscular areas (the needle marks) by the autopsy findings.   Keywords: Forensic medicine; Autopsy; Cause of death; Manner of death; Murder; Midazolam; LC/MS; GC/MS; Forensic pathology<p /> <p>Language: en</p>",
language="en",
issn="2472-1026",
doi="10.4172/2472-1026.1000121",
url="http://dx.doi.org/10.4172/2472-1026.1000121"
}