@article{ref1,
title="Food Poisoning by Ginkgo Seeds through Vitamin B6 Depletion",
journal="Yakugaku Zasshi",
year="2019",
author="Kobayashi, Daisuke",
volume="139",
number="1",
pages="1-6",
abstract="Overconsumption of Ginkgo biloba seeds induces food poisoning characterized by tonic-clonic convulsions and vomiting. The primary toxic component, 4'-O-methylpyridoxine (MPN), was purified from the seeds in 1985. This review includes the following aspects of ginkgo seed poisoning: 1) toxicity related to the content of MPN and MPN glucoside in G. biloba seeds; 2) the effect of MPN on vitamin B<sub>6</sub> analogs, including an increase in pyridoxal and pyridoxic acid and decrease in pyridoxal-5'-phosphate plasma concentrations; 3) case reports of ginkgo seed poisoning in Asia, North America, and Europe, and their effective treatment via vitamin B<sub>6</sub> administration. Considering the increase in the use of G. biloba seeds, it is essential to raise global awareness of their potential toxicity.<p /> <p>Language: ja</p>",
language="ja",
issn="0031-6903",
doi="10.1248/yakushi.18-00136",
url="http://dx.doi.org/10.1248/yakushi.18-00136"
}