@article{ref1,
title="Multisensory logic of infant-directed aggression by males",
journal="Cell",
year="2018",
author="Isogai, Yoh and Wu, Zheng and Love, Michael I. and Ahn, Michael Ho-Young and Bambah-Mukku, Dhananjay and Hua, Vivian and Farrell, Karolina and Dulac, Catherine",
volume="175",
number="7",
pages="1827-1841.e17",
abstract="Newborn mice emit signals that promote parenting from mothers and fathers but trigger aggressive responses from virgin males. Although pup-directed attacks by males require vomeronasal function, the specific infant cues that elicit this behavior are unknown. We developed a behavioral paradigm based on reconstituted pup cues and showed that discrete infant morphological features combined with salivary chemosignals elicit robust male aggression. Seven vomeronasal receptors were identified based on infant-mediated activity, and the involvement of two receptors, Vmn2r65 and Vmn2r88, in infant-directed aggression was demonstrated by genetic deletion. Using the activation of these receptors as readouts for biochemical fractionation, we isolated two pheromonal compounds, the submandibular gland protein C and hemoglobins. Unexpectedly, none of the identified vomeronasal receptors and associated cues were specific to pups. Thus, infant-mediated aggression by virgin males relies on the recognition of pup's physical traits in addition to parental and infant chemical cues.<br><br>Copyright © 2018 Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0092-8674",
doi="10.1016/j.cell.2018.11.032",
url="http://dx.doi.org/10.1016/j.cell.2018.11.032"
}