@article{ref1,
title="High-sensitivity C-reactive protein: retrospective study of potential blood biomarker of inflammation in acute mild traumatic brain injury",
journal="Journal of head trauma rehabilitation",
year="2019",
author="Shetty, Teena and Cogsil, Taylor and Dalal, Aashka and Kim, Esther and Halvorsen, Kristin and Cummings, Kelianne and Nguyen, Joseph T.",
volume="34",
number="3",
pages="E28-E36",
abstract="OBJECTIVE: A panel of biomarkers is needed to definitively diagnose mild traumatic brain injury (mTBI). There is a clear role for the inclusion of an inflammatory biomarker. This study looked to find a relationship between high sensitivity C-reactive protein (hsCRP), an inflammatory biomarker, and mTBI. SETTING: Neurology department of high-volume tertiary orthopedic hospital. PARTICIPANTS: Individuals diagnosed with mTBI (n = 311, age 21 ± 12 years, 53% female). <br><br>DESIGN: Retrospective cohort study. MAIN MEASURES: hsCRP levels; postconcussive symptoms; demographics. <br><br>RESULTS: Continuous hsCRP levels were transformed into quartiles, as defined by less than 0.200 mg/L for quartile 1 (Q1); 0.200 to 0.415 mg/L for quartile 2 (Q2); 0.415 to 1.100 mg/L for quartile 3 (Q3); and greater than 1.100 mg/L for quartile 4 (Q4). Mean hsCRP was elevated in the cohort of individuals who presented within 1 week of injury and was found to significantly decrease between the first visit and 4 weeks postinjury (P =.016). Initial hsCRP level was positively correlated with age (r = 0.163, P =.004), and age significantly increased between quartiles (P =.013). Patients with increased age (odds ratio: 3.48) and those who endorsed headache (odds ratio: 3.48) or fatigue (odds ratio: 2.16) were significantly associated with increased risk of having an hsCRP level in Q4. <br><br>CONCLUSION: hsCRP may be a viable addition to acute and longitudinal biomarker panels for diagnosis and prognosis of mTBI.<p /> <p>Language: en</p>",
language="en",
issn="0885-9701",
doi="10.1097/HTR.0000000000000450",
url="http://dx.doi.org/10.1097/HTR.0000000000000450"
}