@article{ref1,
title="Blast-induced brain injury in rats leads to transient vestibulomotor deficits and persistent orofacial pain",
journal="Brain injury",
year="2018",
author="Studlack, Paige E. and Keledjian, Kaspar and Farooq, Tayyiaba and Akintola, Titilola and Gerzanich, Volodymyr and Simard, J. Marc and Keller, Asaf",
volume="32",
number="13-14",
pages="1866-1878",
abstract="Blast-induced traumatic brain injury (blast-TBI) is associated with vestibulomotor dysfunction, persistent post-traumatic headaches and post-traumatic stress disorder, requiring extensive treatments and reducing quality-of-life. Treatment and prevention of these devastating outcomes require an understanding of their underlying pathophysiology through studies that take advantage of animal models. Here, we report that cranium-directed blast-TBI in rats results in signs of pain that last at least 8 weeks after injury. These occur without significantly elevated behavioural markers of anxiety-like conditions and are not associated with glial up-regulation in sensory thalamic nuclei. These injuries also produce transient vestibulomotor abnormalities that resolve within 3 weeks of injury. Thus, blast-TBI in rats recapitulates aspects of the human condition.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2018.1536282",
url="http://dx.doi.org/10.1080/02699052.2018.1536282"
}