@article{ref1,
title="Interventions for frail community-dwelling older adults have no significant effect on adverse outcomes: a systematic review and meta-analysis",
journal="BMC geriatrics",
year="2018",
author="Van der Elst, Michaël and Schoenmakers, Birgitte and Duppen, Daan and Lambotte, Deborah and Fret, Bram and Vaes, Bert and De Lepeleire, Jan",
volume="18",
number="1",
pages="e249-e249",
abstract="BACKGROUND: According to some studies, interventions can prevent or delay frailty, but their effect in preventing adverse outcomes in frail community-dwelling older people is unclear. The aim is to investigate the effect of an intervention on adverse outcomes in frail older adults. <br><br>METHODS: A systematic review and meta-analysis of Medline, Embase, the Cochrane Library, and Social Sciences Citation Index. Randomized controlled studies that aimed to treat frail community-dwelling older adults, were included. The outcomes were mortality, hospitalization, formal health costs, accidental falls, and institutionalization. Several sub-analyses were performed (duration of intervention, average age, dimension, recruitment). <br><br>RESULTS: Twenty-five articles (16 original studies) were included. Six types of interventions were found. The pooled odds ratios (OR) for mortality when allocated in the experimental group were 0.99 [95% CI: 0.79, 1.25] for case management and 0.78 [95% CI: 0.41, 1.45] for provision information intervention. For institutionalization, the pooled OR with case management was 0.92 [95% CI: 0.63, 1.32], and the pooled OR for information provision intervention was 1.53 [95% CI: 0.64, 3.65]. The pooled OR for hospitalization when allocated in the experimental group was 1.13 [95% CI: 0.95, 1.35] for case management. Further sub-analyses did not yield any significant findings. <br><br>CONCLUSION: This systematic review and meta-analysis does not provide sufficient scientific evidence that interventions by frail older adults can be protective against the included adverse outcomes. A sub-analysis for some variables yielded no significant effects, although some findings suggested a decrease in adverse outcomes. TRIAL REGISTRATION: Prospero registration CRD42016035429.<p /> <p>Language: en</p>",
language="en",
issn="1471-2318",
doi="10.1186/s12877-018-0936-7",
url="http://dx.doi.org/10.1186/s12877-018-0936-7"
}