@article{ref1,
title="Implementation of the Electronic Columbia-Suicide Severity Rating Scale (eC-SSRS™) across four phase IIIb clinical trials in HIV-infected individuals (ARIA, STRIIVING, DAWNING and INSPIRING)",
journal="Innovations in clinical neuroscience",
year="2018",
author="Brennan, Clare and Whillis, Hannah and Man, Choy and Wynne, Brian and Vannappagari, Vani",
volume="15",
number="7-8",
pages="15-19",
abstract="<b>Objective</b>: Increased rates of suicidal ideation/behavior have been reported in individuals with human immunodeficiency virus infection/acquired immunodeficiency syndrome. The electronic Columbia-Suicidality Severity Rating Scale (eC-SSRS™) is a validated tool for assessment of suicidal risk. The objective of this study was to assess the site perspectives on implementation of the eC-SSRS used in Phase IIIb studies of dolutegravir. <b>Methods</b>: We developed and validated the ViiV eC-SSRS Metrics and Perspectives Site Questionnaire (VEQ). Topics included ease of eC-SSRS administration, agreement with clinical assessment, unreported risk, and confidence in utility of the eC-SSRS. <b>Results</b>: Clinical data from two Phase IIIb studies were reviewed for correlation with the eC-SSRS results. The overall VEQ response rate was 83%. A total of 85% of respondents administered the eC-SSRS by phone, and 34% reported their patients would be unable to complete a web survey. First-time eC-SSRS users made up 64% of the responders; 85% of repeat administrators said implementation became easier over time. One-half said the eC-SSRS accurately predicted risk, and 14% said the eC-SSRS identified previously unreported risk. A total of 65% were somewhat/very confident their patients are being assessed accurately for suicide risk. <b>Conclusion</b>: Results of the eC-SSRS from ARIA and STRIIVING were consistent with the clinical data. The eC-SSRS identified previous unreported risk for suicidality and provided physicians opportunity for follow-up. Respondents felt the eC-SSRS helps them manage suicide risk, and they reported that its administration became easier with experience. Thus, the eC-SSRS is considered a useful tool in this setting.<p /> <p>Language: en</p>",
language="en",
issn="2158-8333",
doi="",
url="http://dx.doi.org/"
}