@article{ref1,
title="Patient-reported and performance-based measures of walking in mild-moderate Parkinson's disease",
journal="Brain and behavior",
year="2018",
author="Leavy, Breiffni and Löfgren, Niklas and Nilsson, Maria and Franzén, Erika",
volume="8",
number="9",
pages="e01081-e01081",
abstract="BACKGROUND: Knowledge of the relationships between patient-reported and performance-based walking measures in Parkinson's disease (PD) should inform clinical decision-making. The Walk-12G reliably captures perceived walking difficulties but has not been compared to performance-based walking in laboratory or free-living settings or across different groups. <br><br>OBJECTIVES: To investigate the relationship between patient-reported walking difficulties (Walk-12G) and performance-based walking in laboratory and free-living conditions and to determine whether the Walk-12G can distinguish between the subgroups, (i) people with/without PD and (ii) mild/moderate disease stages. <br><br>METHODS: Forty-seven people without and 49 people with PD (Hoehn and Yahr stage II and III) were assessed in relation to patient-reported walking difficulties (Walk-12G scale); spatiotemporal gait characteristics (Pace; Rhythm; Asymmetry; Variability; and Postural control) using a laboratory-based electronic walkway; and walking behavior (mean steps/day and minutes of brisk walking/day) using accelerometers in free-living conditions. <br><br>RESULTS: The Walk-12G correlated moderately with the spatiotemporal domain step velocity (r = -0.46) and walking behavior, measured as mean steps/day (r = -0.46). Weaker correlations were observed for step length and minutes spent in brisk walking (r = -0.36 and r = -0.35, respectively). Poor correlations were observed for all other spatiotemporal domains. The Walk-12G could distinguish between people with and without PD (Effect size, r = 0.82) and between those at mild/moderate disease stages (r = 0.34). <br><br>CONCLUSIONS: Perceived walking difficulties showed weak to moderate associations with performance-based measures of walking in mild-moderate PD. As the strongest associations were observed for step velocity and walking behavior, targeting these specific gait aspects could improve perceived walking difficulties in daily life.<br><br>© 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.<p /> <p>Language: en</p>",
language="en",
issn="2162-3279",
doi="10.1002/brb3.1081",
url="http://dx.doi.org/10.1002/brb3.1081"
}