@article{ref1,
title="Aggression among 216 patients with a first-psychotic episode of bipolar I disorder",
journal="International journal of bipolar disorders",
year="2018",
author="Khalsa, Hari-Mandir K. and Baldessarini, Ross J. and Tohen, Mauricio and Salvatore, Paola",
volume="6",
number="1",
pages="e18-e18",
abstract="BACKGROUND: Aggression by patients with bipolar I disorder (BD-I) is not uncommon. Identifying potential risk factors early in the illness-course should inform clinical management and reduce risk. <br><br>METHODS: In a study sample of 216 initially hospitalized, first-psychotic episode subjects diagnosed with DSM-IV-TR BD-I, we identified recent (within 1 month before hospitalization) aggression by ratings on the Brief Psychiatric Rating Scale-Expanded and review of detailed clinical research records. We compared subjects with versus without aggressive behavior for associations with selected demographic and clinical factors. <br><br>RESULTS: Aggression was identified in 23/216 subjects (10.6%). It was associated significantly with recent suicide attempt (OR = 4.86), alcohol abuse (OR = 3.63), learning disability (OR = 3.14), and initial manic episode (OR = 2.59), but not with age, sex, onset-type, personality disorder, time to recovery, or functional status. <br><br>CONCLUSIONS: Among first-major episode BD-I patients with psychotic features, recent serious aggression towards others was identified in 10.6%. The odds of aggression increased by 4.9-times in association with a recent suicide attempt, more than 3-times with alcohol-abuse or learning disability, and by 2.6-times if the episode polarity was manic. The findings encourage closer management of alcohol misuse, suicide risk, and manic symptoms, and early detection of learning problems in BD-I patients.<p /> <p>Language: en</p>",
language="en",
issn="2194-7511",
doi="10.1186/s40345-018-0126-8",
url="http://dx.doi.org/10.1186/s40345-018-0126-8"
}