@article{ref1,
title="Decreases in white matter integrity of ventrolimbic pathway linked to posttraumatic stress disorder in mild traumatic brain injury",
journal="Journal of neurotrauma",
year="2019",
author="Santhanam, Priya and Teslovich, Theresa and Wilson, Steffanie H. and Yeh, Ping-Hong and Oakes, Terrence R. and Weaver, Lindell",
volume="36",
number="7",
pages="1093-1098",
abstract="Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well-understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white matter tracts and PTSD symptoms in an mTBI population. Diffusion tensor imaging with probabilistic tractography of the fronto-limbic pathways revealed decreased white matter integrity in the uncinate fasciculus in those with comorbid mTBI and PTSD (n=34), relative to those with only mTBI (n=35). Additionally, fractional anisotropy and radial diffusivity measures in the bilateral uncinate fasciculus correlated with PTSD checklist (PCL-C) scores, and primarily within the avoidance and re-experiencing domains. <br><br>FINDINGS from this study suggest the degree of traumatic injury within the limbic system could be directly related to post-traumatic stress and post-concussive symptoms, with disrupted white matter leading to significant PTSD outcomes.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2017.5541",
url="http://dx.doi.org/10.1089/neu.2017.5541"
}