@article{ref1,
title="Neuromodulatory treatments for alcohol use disorder: a review",
journal="Brain sciences",
year="2018",
author="Salib, Anne-Mary N. and Ho, Allen L. and Sussman, Eric S. and Pendharkar, Arjun V. and Halpern, Casey H.",
volume="8",
number="6",
pages="e8060095-e8060095",
abstract="Alcohol use disorder (AUD) is a prevalent condition characterized by chronic alcohol-seeking behaviors and has become a significant economic burden with global ramifications on public health. While numerous treatment options are available for AUD, many are unable to sustain long-term sobriety. The nucleus accumbens (NAcc) upholds an integral role in mediating reward behavior and has been implicated as a potential target for deep brain stimulation (DBS) in the context of AUD. DBS is empirically thought to disrupt pathological neuronal synchrony, a hallmark of binge behavior. Pre-clinical animal models and pilot human clinical studies utilizing DBS for the treatment of AUD have shown promise for reducing alcohol-related cravings and prolonging abstinence. In this review, we outline the various interventions available for AUD, and the translational potential DBS has to modulate functionality of the NAcc as a treatment for AUD.<p /> <p>Language: en</p>",
language="en",
issn="2076-3425",
doi="10.3390/brainsci8060095",
url="http://dx.doi.org/10.3390/brainsci8060095"
}