@article{ref1,
title="Deep brain stimulation in a rat model of post-traumatic stress disorder modifies forebrain neuronal activity and serum corticosterone",
journal="Iranian journal of basic medical sciences",
year="2018",
author="Hashtjini, Mina Mokhtari and Jahromi, Gila Pirzad and Sadr, Seyed Shahabeddin and Meftahi, Gholam Hossein and Hatef, Boshra and Javidnazar, Danial",
volume="21",
number="4",
pages="370-375",
abstract="OBJECTIVES: Post-traumatic stress disorder (PTSD), one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event followed by intense fear. In rats with contextual fear conditioning (CFC), a model of PTSD caused by CFC (electrical foot shock chamber), deep brain stimulation (DBS) alleviates CFC abnormalities. <br><br>MATERIALS AND METHODS: Forty Male Wistar rats (220-250 g) were divided into 5 groups (n=8) and underwent stereotactic surgery to implant electrodes in the right basolateral nucleus of the amygdala (BLn). After 7 days, some animals received a foot shock, followed by another 7-day treatment schedule (DBS treatment). Next, freezing behavior was measured as a predicted response in the absence of the foot shock (re-exposure time). Blood serum corticosterone levels and amygdala c-Fos protein expression were assessed using Enzyme-linked immunosorbent assay (ELISA) and Western blot, respectively. Furthermore, freezing behaviors by re-exposure time test and general anxiety by elevated plus-maze (EPM) were evaluated. <br><br>RESULTS: PTSD decreased serum corticosterone levels and increased both amygdala c-Fos expression and freezing behaviors. Therefore, DBS treatment significantly (<i>P</i><0.001) enhanced serum corticosterone levels and could significantly (<i>P</i><0.001) reduce both c-Fos protein expression and freezing behaviors' duration. However, DBS treatment has no effect on the general anxiety in PTSD rats. <br><br>CONCLUSION: We argue that these outcomes might demonstrate the mechanism of DBS treatment, a complete therapeutic strategy, in PTSD patients.<p /> <p>Language: en</p>",
language="en",
issn="2008-3866",
doi="10.22038/IJBMS.2018.27482.6705",
url="http://dx.doi.org/10.22038/IJBMS.2018.27482.6705"
}