@article{ref1,
title="Psychotic-like experiences in pre-adolescence: what precedes the antecedent symptoms of severe mental illness?",
journal="Acta psychiatrica Scandinavica",
year="2018",
author="Bolhuis, K. and Koopman-Verhoeff, M. E. and Blanken, L. M. E. and Cibrev, D. and Jaddoe, V. W. V. and Verhulst, F. C. and Hillegers, M. H. J. and Kushner, S. A. and Tiemeier, H.",
volume="138",
number="1",
pages="15-25",
abstract="OBJECTIVE: Adolescent psychotic-like experiences predict the onset of psychosis, but also predict subsequent non-psychotic disorders. Therefore, it is crucial to better understand the aetiology of psychotic-like experiences. This study examined whether (a) child emotional and behavioural problems at 3 and 6 years, or (b) childhood adversities were associated with psychotic-like experiences at age 10 years. <br><br>METHOD: This prospective study was embedded in the Generation R Study; 3984 children (mean age 10 years) completed a psychotic-like experiences questionnaire. Mothers reported problems of their child at ages 3, 6 and 10 years. Additionally, mothers were interviewed about their child's adversities. <br><br>RESULTS: Psychotic-like experiences were endorsed by ~20% of children and predicted by both emotional and behavioural problems at 3 years (e.g. emotional-reactive problems: OR<sub>adjusted</sub> = 1.10, 95% CI: 1.06-1.15, aggressive behaviour: OR<sub>adjusted</sub> = 1.03, 95% CI: 1.02-1.05) and 6 years (e.g. anxious/depressed problems: OR<sub>adjusted</sub> = 1.11, 95% CI: 1.06-1.15, aggressive behaviour: OR<sub>adjusted</sub> = 1.04, 95% CI: 1.04-1.05). Childhood adversities were associated with psychotic-like experiences (>2 adversities: OR<sub>adjusted</sub> = 2.24, 95% CI: 1.72-2.92), which remained significant after adjustment for comorbid psychiatric problems. <br><br>CONCLUSION: This study demonstrated associations between early adversities, childhood emotional and behavioural problems and pre-adolescent psychotic-like experiences, which will improve the understanding of children at increased risk of severe mental illness.<br><br>© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.<p /> <p>Language: en</p>",
language="en",
issn="0001-690X",
doi="10.1111/acps.12891",
url="http://dx.doi.org/10.1111/acps.12891"
}