@article{ref1,
title="Psychotic (delusional) depression and suicidal attempts: a systematic review and meta-analysis",
journal="Acta psychiatrica Scandinavica",
year="2018",
author="Gournellis, R. and Tournikioti, K. and Touloumi, G. and Thomadakis, C. and Michalopoulou, P. G. and Christodoulou, C. and Papadopoulou, A. and Douzenis, A.",
volume="137",
number="1",
pages="18-29",
abstract="OBJECTIVE: It still remains unclear whether psychotic features increase the risk of suicidal attempts in major depressive disorder. Thus, we attempted, through a systematic review coupled with a meta-analysis, to elucidate further whether unipolar psychotic depression (PMD) compared to non-PMD presents higher levels of suicidal attempts. <br><br>METHOD: A systematic search was conducted in PubMed, EMBASE, PsycINFO as well as in various databases of the so-called gray literature for all studies providing data on suicidal attempts in PMD compared to non-PMD, and the results were then subjected to meta-analysis. <br><br>RESULTS: Twenty studies met our inclusion criteria, including in total 1,275 PMD patients and 5,761 non-PMD patients. An elevated risk for suicide attempt for PMD compared to non-PMD patients was found: The total (lifetime) fixed-effects pooled OR was 2.11 (95% CI: 1.81-2.47), and the fixed-effects pooled OR of the five studies of the acute phase of the disorder was 1.93 (95% CI: 1.33-2.80). This elevated risk of suicidal attempt for PMD patients remained stable across all age groups of adult patients. <br><br>CONCLUSION: Despite data inconsistency and clinical heterogeneity, this systematic review and meta-analysis showed that patients with PMD are at a two-fold higher risk, both during lifetime and in acute phase, of committing a suicidal attempt than patients with non-PMD.<br><br>© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.<p /> <p>Language: en</p>",
language="en",
issn="0001-690X",
doi="10.1111/acps.12826",
url="http://dx.doi.org/10.1111/acps.12826"
}