@article{ref1,
title="Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review",
journal="Brain injury",
year="2018",
author="Mercier, Eric and Tardif, Pier-Alexandre and Cameron, Peter A. and Emond, Marcel and Moore, Lynne and Mitra, Biswadev and Ouellet, Marie-Christine and Frenette, Jérôme and De Guise, Elaine and Le Sage, Natalie",
volume="32",
number="1",
pages="29-40",
abstract="BACKGROUND: This systematic review aimed to determine the prognostic value of neuron-specific enolase (NSE) to predict post-concussion symptoms following mild traumatic brain injury (TBI). <br><br>METHODS: Seven databases were searched for studies evaluating the association between NSE levels and post-concussion symptoms assessed ≥ 3 months (persistent) or ≥ 7 days < 3 months (early) after mild TBI. Two researchers independently screened studies for inclusion, extracted data and appraised quality using the Quality in Prognostic Studies (QUIPS) tool. <br><br>RESULTS: The search strategy yielded a total of 23,298 citations from which 8 cohorts presented in 10 studies were included. Studies included between 45 and 141 patients (total 608 patients). The outcomes most frequently assessed were post-concussion syndrome (PCS, 12 assessments) and neuropsychological performance deficits (10 assessments). No association was found between an elevated NSE serum level and PCS. Only one study reported a statistically significant association between a higher NSE serum level and alteration of at least three cognitive domains at 2 weeks but this association was no longer significant at 6 weeks. Overall, risk of bias of the included studies was considered moderate. <br><br>CONCLUSIONS: Early NSE serum level is not a strong independent predictor of post-concussion symptoms following mild TBI.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2017.1385097",
url="http://dx.doi.org/10.1080/02699052.2017.1385097"
}